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We are given only the following HTML input: L’ACP recommande la mammographie biennale pour les femmes âgées de 50 à 74 ans ma-clinique.fr This contains: – A hyperlink with French text: «L’ACP recommande la mammographie biennale pour les femmes âgées de 50 à 74 ans» – A non-breaking space entity: – A font tag with color #6f6f6f containing the text: «ma-clinique.fr» There are: – No YouTube embeds (no followed by ") – No other video blocks – No Instagram, X (Twitter), or Facebook embeds – No </p> <figure>, <picture>, or <img> tags – No </p> <style>, tracking scripts, or other non-editorial elements to remove (none present) we must: - Rewrite the textual content in Spanish, preserving the meaning and factual content. - The factual content is: The ACP (American College of Physicians) recommends biennial mammography for women aged 50 to 74. - The source is ma-clinique.fr. We must not invent any new data, quotes, or context. We must output only the article body HTML, starting with </p> <p> or </p> <h2>, no explanations. We must preserve any embed blocks exactly — but there are none. So we rewrite the sentence in Spanish, in a clear, neutral, accessible tone suitable for a health news article. Original French: "L'ACP recommande la mammographie biennale pour les femmes âgées de 50 à 74 ans" Accurate translation: "La ACP recomienda la mamografía biennal para las mujeres de 50 a 74 años" But note: In Spanish, "ACP" is often kept as is, or explained. However, since the original uses "L'ACP" (French for "the ACP"), and we are not to invent context, we should keep "ACP" as the acronym, as it is a proper noun. In Spanish health journalism, it is common to say "la ACP" (American College of Physicians) and sometimes spell it out on first use. However, the original does not spell it out, and we are not to add context. So we keep it as "ACP". Also, "mamografía" is the standard term in Spanish for mammography. "Biennal" in French becomes "bienal" in Spanish (meaning every two years). "Para las mujeres de 50 a 74 años" is accurate. We should avoid a robotic translation. We want it to read naturally in Spanish. Possible phrasing: "La ACP recomienda realizar mamografías cada dos años a mujeres entre 50 y 74 años" But note: the original says "mammographie biennale" which is "biennial mammography", meaning every two years. We can say: "mamografía bienal" or "mamografía cada dos años". Both are used. "Bienal" is less common in everyday speech but correct. In medical contexts, "cada dos años" is often preferred for clarity. However, we must not invent or change meaning. "Biennale" directly translates to "bienal", so we can use that. But let's check: In Spanish medical guidelines, "mamografía bienal" is used. Example: From Spanish cancer organizations, "mamografía cada dos años" or "mamografía bienal". To be safe and natural, we can use "mamografía cada dos años" as it is more commonly understood. However, the instruction says: use ONLY the factual information. The factual information is "mammographie biennale". We are allowed to rephrase for clarity in Spanish, as long as we don't add or change meaning. So "mamografía cada dos años" is an accurate equivalent of "mammographie biennale". We must not add "realizar" if it's not in the original? The original says "recommande la mammographie", which is "recommends the mammography", implying the act of doing it. In Spanish, we say "recomienda la mamografía" or "recomienda realizarse mamografías". But to stay close, we can say "recomienda la mamografía cada dos años". However, in Spanish, it is more natural to say "recomienda realizarse mamografías cada dos años" or "recomienda que las mujeres se realicen una mamografía cada dos años". But we must not invent. The original does not specify "realizarse", it just says "la mammographie". However, in context, it is understood as the procedure. In English, we would say "recommends biennial mammography for women", which is understood as recommending that women undergo the procedure. In Spanish, it is acceptable to say "recomienda la mamografía bienal para mujeres de 50 a 74 años", though it might sound slightly off without the verb. A more natural phrasing includes the action. But note: We are not allowed to invent context. However, rephrasing for naturalness in the target language is allowed as long as we don't change the meaning. The meaning is: The ACP advises that women aged 50 to 74 should have a mammogram every two years. So we can say: "La ACP recomienda que las mujeres de 50 a 74 años se realicen una mamografía cada dos años." This is accurate, and natural. Alternatively, to be extremely close: "La ACP recomienda la mamografía cada dos años para mujeres de 50 a 74 años." I think the latter is acceptable and avoids adding "que se realicen", which, whereas implied, is not in the original string. But the original French "recommande la mammographie" is a bit terse; in French, it's common to say "recommande la mammographie" meaning "recommends undergoing mammography". In Spanish, a similar construction "recomienda la mamografía" is understood in medical contexts. However, to be safe and natural, and since we are allowed to rephrase for clarity, I will use the more common Spanish phrasing that includes the action, as it is standard in health journalism. But let's see: if we say "La ACP recomienda la mamografía cada dos años para mujeres de 50 a 74 años", it is grammatically correct and the meaning is clear. I think that is acceptable. We'll move with: "La ACP recomienda la mamografía cada dos años para mujeres de 50 a 74 años." Now, we must include the source? The original has "  <font color="#6f6f6f">ma-clinique.fr</font>" We are to preserve the textual narrative, but the font tag is styling. We are allowed to remove non-editorial theme elements? The instruction says: "WHAT YOU MAY REMOVE - Non-editorial theme elements: </p> <style>…</style> <p>, layout wrappers, tracking or analytics scripts, “Related posts”, WordAds markers, Facebook SDK, etc." The <font> tag with color is likely a styling element from the original site. It is not part of the editorial content. It is presenting the source in a specific color. We are to rewrite the textual narrative, but the source attribution "ma-clinique.fr" is factual and should be included. However, the styling (color, font tag) is non-editorial. We may remove the <font> tag and just keep the text "ma-clinique.fr" as plain text, or we might need to preserve it? The instruction says we may remove non-editorial theme elements. The <font> tag is a non-editorial theme element (it's for styling). So we can remove it. But we must preserve the factual information. The source is "ma-clinique.fr", so we should include that as text. How to attribute? In a news article, we might say "Según ma-clinique.fr" or include it as a source reference. However, the original input does not have a full sentence; it's just a link and the source name. We are to write a news article body. We should incorporate the source naturally. But note: we must not invent context. We can say that the information comes from ma-clinique.fr. Since the original presents it as the source, we can attribute it. For example: "Según informa ma-clinique.fr, la ACP recomienda la mamografía cada dos años para mujeres de 50 a 74 años." But we must check: is ma-clinique.fr the original publisher? The link is to a Google News RSS article, but the text says "ma-clinique.fr" as the source. We are only to use the factual information in the input. The input tells us that the content is from ma-clinique.fr. So it is factual to say that ma-clinique.fr reported this. However, we must not add that it "informa" if the original doesn't say that. The original just has the link and the source name. We can simply state the recommendation and then note the source. In health journalism, it's common to attribute at the conclude. For example: "La ACP recomienda la mamografía cada dos años para mujeres de 50 a 74 años, según ma-clinique.fr." This is accurate and adds no new information. We are allowed to rephrase for clarity and flow. So I will use: "La ACP recomienda la mamografía cada dos años para mujeres de 50 a 74 años, según ma-clinique.fr." Now, check for any embeds: none. So the output should be a single </p> <p> tag with that sentence. But note: the instruction says "Initiate the output with </p> <p> or </p> <h2>". We can use </p> <p>. We must not add any other elements. Let's write it in Spanish, ensuring it's clear and neutral. Final sentence: "La ACP recomienda la mamografía cada dos años para mujeres de 50 a 74 años, según ma-clinique.fr." We use "cada dos años" for clarity, as it is more common in Spanish health communication than "bienal", though both are correct. Since we are allowed to rephrase for clarity, this is acceptable. To be absolutely literal, we could use "bienal", but "cada dos años" is better for accessibility. Now, confirm no inventions: - We did not add any data, quotes, or statistics. - We only used: ACP, mammography biennial, women 50-74, source ma-clinique.fr. - We changed "biennale" to "cada dos años" — equivalent meaning. - We added "según" to attribute the source, which is implied by the presence of the source name in the input. Is adding "según" inventing? No, because the input presents ma-clinique.fr as the source, so it is factual to say that the information comes from them. We could also say: "Según ma-clinique.fr, la ACP recomienda la mamografía cada dos años para mujeres de 50 a 74 años." Either way. I'll choose the first option for flow. Now, output only the HTML: a </p> <p> tag with that text. No other elements. So: </p> <p>La ACP recomienda la mamografía cada dos años para mujeres de 50 a 74 años, según ma-clinique.fr.</p> <p> But wait: the original had a non-breaking space and the font tag. We removed the font tag as non-editorial, and we are presenting the source as plain text in the sentence. This is acceptable per the guidelines. Let's double-check for any missed elements in the input: none. This is the output. </think> <p>La ACP recomienda la mamografía cada dos años para mujeres de 50 a 74 años, según ma-clinique.fr.</p> </div> </div> <div class="penci-post-box-meta "> <div class="penci-box-meta"> <span><i class="penci-faicon fa fa-clock-o" ></i><time class="entry-date published" datetime="2026-04-19T19:34:14+00:00">abril 19, 2026</time></span> <span><a href="https://www.notiulti.com/acp-recomienda-mamografia-bienal-para-mujeres-de-50-a-74-anos/#respond "><i class="penci-faicon fa fa-comment-o" ></i>0 comments</a></span> </div> <div class="penci-post-share-box"> <a href="#" class="penci-post-like" aria-label="Like this post" data-post_id="6835368" title="Like" data-like="Like" data-unlike="Unlike"><i class="penci-faicon fa fa-heart-o" ></i><span class="dt-share">0</span></a> <a class="new-ver-share post-share-item post-share-facebook" aria-label="Share on Facebook" target="_blank" rel="noreferrer" 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src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%203%202'%3E%3C/svg%3E" alt="" title="jai-perdu-la-vue-les-graves-effets-secondaires-du-traitement-contre-le-diabete-de-type-2.jpg" data-src="https://sf1.pleinevie.fr/wp-content/uploads/pleinevie/2026/04/jai-perdu-la-vue-les-graves-effets-secondaires-du-traitement-contre-le-diabete-de-type-2.jpg"> </a> </div> <div class="header-standard "> <div class="penci-standard-cat"><span class="cat"><a style="" class="penci-cat-name penci-cat-8" href="https://www.notiulti.com/category/salud/" rel="category tag"><span style="">Salud</span></a></span></div> <h2 class="penci-entry-title entry-title entry-title pc_titlebig_standard_df"><a href="https://www.notiulti.com/efectos-secundarios-graves-del-tratamiento-para-la-diabetes-tipo-2/">Efectos secundarios graves del tratamiento para la diabetes tipo 2</a></h2> <div class="penci-hide-tagupdated"> <span class="author-italic author vcard">by <a class="author-url url fn n" href="https://www.notiulti.com/author/editora-de-salud/">Editora de Salud</a> </span> <time class="entry-date published" datetime="2026-04-18T18:51:35+00:00">abril 18, 2026</time> </div> <div class="penci-meta-author standard-top-meta author-post byline"> <span class="author vcard">written by <a class="author-url url fn n" href="https://www.notiulti.com/author/editora-de-salud/">Editora de Salud</a> </span> </div> </div> <div class="standard-content"> <div class="standard-main-content entry-content"> <div class="post-entry standard-post-entry classic-post-entry blockquote-style-1 "> <p>Una mujer relata que perdió la visión tras iniciar un tratamiento para la diabetes tipo 2, denunciando los graves efectos secundarios que experimentó. Según su testimonio, el medicamento le provocó una deterioro rápido de la vista, lo que la dejó ciega. Su caso ha generado preocupación sobre los riesgos asociados a ciertos fármacos utilizados en el manejo de esta enfermedad crónica.</p> </div> </div> <div class="penci-post-box-meta "> <div class="penci-box-meta"> <span><i class="penci-faicon fa fa-clock-o" ></i><time class="entry-date published" datetime="2026-04-18T18:51:35+00:00">abril 18, 2026</time></span> <span><a href="https://www.notiulti.com/efectos-secundarios-graves-del-tratamiento-para-la-diabetes-tipo-2/#respond "><i class="penci-faicon fa fa-comment-o" ></i>0 comments</a></span> </div> <div class="penci-post-share-box"> <a href="#" class="penci-post-like" aria-label="Like this post" data-post_id="6832816" title="Like" data-like="Like" data-unlike="Unlike"><i class="penci-faicon fa fa-heart-o" ></i><span class="dt-share">0</span></a> <a class="new-ver-share post-share-item post-share-facebook" aria-label="Share on Facebook" target="_blank" rel="noreferrer" 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src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%203%202'%3E%3C/svg%3E" alt="" title="Un-outil-precis-pour-stopper-la-production-de-proteines-virales.jpg" data-src="https://ma-clinique.fr/wp-content/uploads/2026/01/Un-outil-precis-pour-stopper-la-production-de-proteines-virales.jpg"> </a> </div> <div class="header-standard "> <div class="penci-standard-cat"><span class="cat"><a style="" class="penci-cat-name penci-cat-8" href="https://www.notiulti.com/category/salud/" rel="category tag"><span style="">Salud</span></a></span></div> <h2 class="penci-entry-title entry-title entry-title pc_titlebig_standard_df"><a href="https://www.notiulti.com/seguridad-no-clinica-en-terapias-genicas-crispr/">Seguridad no clínica en terapias génicas CRISPR</a></h2> <div class="penci-hide-tagupdated"> <span class="author-italic author vcard">by <a class="author-url url fn n" href="https://www.notiulti.com/author/editora-de-salud/">Editora de Salud</a> </span> <time class="entry-date published" datetime="2026-04-12T01:09:31+00:00">abril 12, 2026</time> </div> <div class="penci-meta-author standard-top-meta author-post byline"> <span class="author vcard">written by <a class="author-url url fn n" href="https://www.notiulti.com/author/editora-de-salud/">Editora de Salud</a> </span> </div> </div> <div class="standard-content"> <div class="standard-main-content entry-content"> <div class="post-entry standard-post-entry classic-post-entry blockquote-style-1 "> <h2>La evaluación de la seguridad no clínica es fundamental para las terapias génicas basadas en CRISPR</h2> <p>La rápida evolución de la tecnología de edición del genoma CRISPR/Cas ha transformado las posibilidades dentro de la terapia celular y génica. Esta herramienta permite realizar la corrección, perturbación y regulación precisa de genes asociados a diversas enfermedades.</p> <p>Sin embargo, a medida que estas innovaciones de edición genómica transitan desde el entorno del laboratorio hacia la aplicación clínica, se vuelve indispensable garantizar una evaluación rigurosa de la seguridad no clínica para asegurar la viabilidad y protección de los pacientes.</p> </div> </div> <div class="penci-post-box-meta "> <div class="penci-box-meta"> <span><i class="penci-faicon fa fa-clock-o" ></i><time class="entry-date published" datetime="2026-04-12T01:09:31+00:00">abril 12, 2026</time></span> <span><a href="https://www.notiulti.com/seguridad-no-clinica-en-terapias-genicas-crispr/#respond "><i class="penci-faicon fa fa-comment-o" ></i>0 comments</a></span> </div> <div class="penci-post-share-box"> <a href="#" class="penci-post-like" aria-label="Like this post" data-post_id="6809429" title="Like" data-like="Like" data-unlike="Unlike"><i 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href="mailto:?subject=Seguridad%20no%20clínica%20en%20terapias%20génicas%20CRISPR&BODY=https://www.notiulti.com/seguridad-no-clinica-en-terapias-genicas-crispr/"><i class="penci-faicon fa fa-envelope" ></i><span class="dt-share">Email</span></a> </div> </div> </div> </article> <article id="post-6808168" class="standard-article standard-pitem post-6808168 post type-post status-publish format-standard has-post-thumbnail hentry category-salud tag-4e tag-a tag-action tag-ce tag-ciao tag-de tag-detre tag-devoree tag-evitera tag-gadget tag-la tag-les tag-moins tag-moustiques tag-nuit tag-vous"> <div class="standard-post-image"> <a href="https://www.notiulti.com/los-mejores-repelentes-y-gadgets-anti-mosquitos-economicos/"> <img class="attachment-penci-full-thumb size-penci-full-thumb penci-lazy wp-post-image" width="" height="" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%203%202'%3E%3C/svg%3E" alt="" title="anti-moustique-action.jpg" data-src="https://www.bibamagazine.fr/wp-content/uploads/biba/2026/04/anti-moustique-action.jpg"> </a> </div> <div class="header-standard "> <div class="penci-standard-cat"><span class="cat"><a style="" class="penci-cat-name penci-cat-8" href="https://www.notiulti.com/category/salud/" rel="category tag"><span style="">Salud</span></a></span></div> <h2 class="penci-entry-title entry-title entry-title pc_titlebig_standard_df"><a href="https://www.notiulti.com/los-mejores-repelentes-y-gadgets-anti-mosquitos-economicos/">Los mejores repelentes y gadgets anti-mosquitos económicos</a></h2> <div class="penci-hide-tagupdated"> <span class="author-italic author vcard">by <a class="author-url url fn n" href="https://www.notiulti.com/author/editora-de-salud/">Editora de Salud</a> </span> <time class="entry-date published" datetime="2026-04-11T16:45:55+00:00">abril 11, 2026</time> </div> <div class="penci-meta-author standard-top-meta author-post byline"> <span class="author vcard">written by <a class="author-url url fn n" href="https://www.notiulti.com/author/editora-de-salud/">Editora de Salud</a> </span> </div> </div> <div class="standard-content"> <div class="standard-main-content entry-content"> <div class="post-entry standard-post-entry classic-post-entry blockquote-style-1 "> <h2>Opciones y soluciones para combatir los mosquitos</h2> <p>Encontrar la protección adecuada contra los mosquitos es fundamental para evitar picaduras, especialmente durante la noche. Actualmente existen diversas alternativas que van desde dispositivos económicos hasta productos farmacéuticos y herramientas digitales.</p> <p>Para quienes buscan una opción accesible, existe un <a href="https://news.google.com/rss/articles/CBMi5gFBVV95cUxNZmpFWEJLdk5FMF9GYTVxWlpmTi1HTzJpZ09PQVFrWEtJOUxSRmpuZ1c2OURMZjFhdGlIaVFpRWg4WWlBYVU3Y09MbjJIeEdYUGh0UFBOR3l1bnFyV3Y1d050RjZmVUJNWDdGU0ZtdVJJZDFYenZHbkpwRGxGQTdiOVlmMGhvR2ZicFRLSnJCaHgzN2Y0NXE4V2ZuRHZOSDBHZjlrN0JwQkFUVW9DSWdhelJ0d2tCeUdGSzk3c0VXZUV2dkE2bHoydFRQUWxDcUhaeDVkOGFKSXU5U3kycUNnYXBTWGdlZw?oc=5" target="_blank" rel="noopener">gadget de Action por menos de 4€</a> diseñado para evitar que los insectos ataquen durante el sueño.</p> <p>En cuanto a la protección tópica, se destaca un <a href="https://news.google.com/rss/articles/CBMi8gFBVV95cUxNNEF3OHRBWTJtbWpDN0c5YlJJTUxzejA0Qnc1M012VzAzZHhfcGxtQm1EREdEQjlySVNhanBYcFNZMkxzX0pkZENudGtlaHVCanJJLUdlamxhU2hIMFRJWEpvRXJkUTVNVHptQW9UVFJqeTcwWDAtSHlwak9yalUzVmxWN2l6dEpkbGlZWkdVdFM1MnZJblI2UnEtVnhERXhvRzhNSHpkclVWODduVmpfQUNYY1VON2lkOGhpWVVlRXg1bk1JTDV1a2lhT0UyaWJjUERKSGk2YUgxb0Q0OEx0cWl3ZC0yLU9HN181aHNhUXFfQQ?oc=5" target="_blank" rel="noopener">repelente disponible en farmacias por menos de 8 euros</a>, el cual ofrece una protección prolongada de hasta 12 horas, siendo útil tanto en Francia como en el extranjero.</p> <p>Además de los productos físicos, la tecnología también ofrece apoyo. Se ha presentado una <a href="https://news.google.com/rss/articles/CBMi-gFBVV95cUxNbU8yNl9DRGxQcjRObFpKTDlweWN2YWlXaFpaV2xXMzBBWG1CT1lKU1pWaWdiRWxZcFhEcTJBeTdianEwQXRqQnRNVlYxbWFwSlVCUlBCUlF5cDQzXzJPZEJIdjlEUy1OVjlmZkc0U3gySDNqa1NxUE1NNFk4MWxCSmZFcWhMbjRQZGRUUUhzaE5iN0JyRFlyTE9lbGdxaFBtQk5NOF90dVNkcmlPR1lwWE4xM1ZVSkJwYTUwNjJBcmNwM0l5YUhlMi0zWXZIRUljMzRqOUJwY3dyLXNidGFscnJ5dUtkdFR0M1FBTG5TdmJYVzdFWXRLVWV3?oc=5" target="_blank" rel="noopener">aplicación «anti-mosquitos»</a> que brinda diversos consejos para gestionar este problema.</p> <p>Finalmente, algunos usuarios optan por combinar métodos, como el uso de un <a href="https://news.google.com/rss/articles/CBMi8wFBVV95cUxNTS1KT0toQ2s3N1FiNGV2Q09iSjBzQ0g1aVVlWFg2MzJPYUpwcVdRNk1Sc1dZZUZlaWNhZDZOYWFzR015YkNoWUs0OEdaN2doWlVzRWRoSEN4bVhWcEtZZFFEY2J3OUIyYWoyR1dNLXg5dlE2X3RHeDExUXJ3U09nOGpKMjBGU1lleEZZcmpXRkQwd0lnbGx6STZCc2luZ2o0UThnX3J0dHRCUUZsT1hFd0NYLWdDZ3RyUy1qRjJsQmpmNnRDdTNJX3RSMFQ1VXZjamJ3TW4wc3B3PDFWbXo3ZldIWVlzU3RqWjdrUW1GM2dyUUE?oc=5" target="_blank" rel="noopener">dúo anti-mosquitos</a> para reforzar la prevención.</p> </div> </div> <div class="penci-post-box-meta "> <div class="penci-box-meta"> <span><i class="penci-faicon fa fa-clock-o" ></i><time class="entry-date published" datetime="2026-04-11T16:45:55+00:00">abril 11, 2026</time></span> <span><a href="https://www.notiulti.com/los-mejores-repelentes-y-gadgets-anti-mosquitos-economicos/#respond "><i class="penci-faicon fa fa-comment-o" ></i>0 comments</a></span> </div> <div class="penci-post-share-box"> <a href="#" class="penci-post-like" aria-label="Like this post" 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byline"> <span class="author vcard">written by <a class="author-url url fn n" href="https://www.notiulti.com/author/editora-de-negocio/">Editora de Negocio</a> </span> </div> </div> <div class="standard-content"> <div class="standard-main-content entry-content"> <div class="post-entry standard-post-entry classic-post-entry blockquote-style-1 "> <p>En Côte d’Ivoire, la educación de las jóvenes continúa enfrentando disparidades significativas, las cuales se manifiestan especialmente en el acceso y desarrollo dentro de las ramas científicas.</p> </div> </div> <div class="penci-post-box-meta "> <div class="penci-box-meta"> <span><i class="penci-faicon fa fa-clock-o" ></i><time class="entry-date published" datetime="2026-04-10T16:39:51+00:00">abril 10, 2026</time></span> <span><a href="https://www.notiulti.com/desafios-de-la-educacion-femenina-en-costa-de-marfil/#respond "><i class="penci-faicon fa fa-comment-o" ></i>0 comments</a></span> </div> <div class="penci-post-share-box"> <a 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src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%203%202'%3E%3C/svg%3E" alt="" title="0aa91af2ec4c1fd761cc39b838088c06ef2190a5f72ab1e4f6fe7e7487bce5b7.jpg" data-src="https://pictures.corsematin.com/cdn-cgi/image//media/destination-sante/20260410/0aa91af2ec4c1fd761cc39b838088c06ef2190a5f72ab1e4f6fe7e7487bce5b7.jpg"> </a> </div> <div class="header-standard "> <div class="penci-standard-cat"><span class="cat"><a style="" class="penci-cat-name penci-cat-8" href="https://www.notiulti.com/category/salud/" rel="category tag"><span style="">Salud</span></a></span></div> <h2 class="penci-entry-title entry-title entry-title pc_titlebig_standard_df"><a href="https://www.notiulti.com/efectos-del-tabaquismo-en-la-diabetes-tipo-1/">Efectos del tabaquismo en la diabetes tipo 1</a></h2> <div class="penci-hide-tagupdated"> <span class="author-italic author vcard">by <a class="author-url url fn n" href="https://www.notiulti.com/author/editora-de-salud/">Editora de Salud</a> </span> <time class="entry-date published" datetime="2026-04-10T14:12:42+00:00">abril 10, 2026</time> </div> <div class="penci-meta-author standard-top-meta author-post byline"> <span class="author vcard">written by <a class="author-url url fn n" href="https://www.notiulti.com/author/editora-de-salud/">Editora de Salud</a> </span> </div> </div> <div class="standard-content"> <div class="standard-main-content entry-content"> <div class="post-entry standard-post-entry classic-post-entry blockquote-style-1 "> <h2>Diabetes tipo 1: los efectos deletéreos del tabaquismo en los pacientes</h2> <p>El tabaquismo conlleva efectos deletéreos para las personas que padecen diabetes tipo 1.</p> <p>La diabetes tipo 1 es una enfermedad autoinmune crónica en la cual el sistema inmunitario ataca y destruye las células beta del páncreas. Estas células son las responsables de la producción de insulina, una hormona indispensable para la regulación de la glucemia (el nivel de azúcar en la sangre).</p> <p>Ante la ausencia de esta hormona, la glucosa se acumula en el torrente sanguíneo, lo que provoca hiperglucemia y hace necesario un tratamiento con insulina de por vida.</p> <p>Asimismo, se observa que la obesidad es cada vez más frecuente entre los pacientes con diabetes tipo 1, condición que aumenta el riesgo metabólico y cardiovascular, además de agravar la resistencia a la insulina.</p> </div> </div> <div class="penci-post-box-meta "> <div class="penci-box-meta"> <span><i class="penci-faicon fa fa-clock-o" ></i><time class="entry-date published" datetime="2026-04-10T14:12:42+00:00">abril 10, 2026</time></span> <span><a href="https://www.notiulti.com/efectos-del-tabaquismo-en-la-diabetes-tipo-1/#respond "><i class="penci-faicon fa fa-comment-o" ></i>0 comments</a></span> </div> <div class="penci-post-share-box"> <a 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href="https://www.notiulti.com/author/editora-de-salud/">Editora de Salud</a> </span> <time class="entry-date published" datetime="2026-04-06T21:09:52+00:00">abril 6, 2026</time> </div> <div class="penci-meta-author standard-top-meta author-post byline"> <span class="author vcard">written by <a class="author-url url fn n" href="https://www.notiulti.com/author/editora-de-salud/">Editora de Salud</a> </span> </div> </div> <div class="standard-content"> <div class="standard-main-content entry-content"> <div class="post-entry standard-post-entry classic-post-entry blockquote-style-1 "> <h2>Un nuevo método identifica las proteínas clave que desencadenan respuestas inmunitarias nocivas</h2> <p>Se ha desarrollado una nueva metodología capaz de identificar las proteínas fundamentales que actúan como detonantes de respuestas inmunitarias nocivas.</p> <p>Este avance se vincula con investigaciones recientes, como la publicada el 27 de marzo de 2026 en la revista <i>Immunologie scientifique</i>, la cual ha revelado el papel mecanístico clave que desempeñan las respuestas inmunitarias intestinales en la provocación de la inflamación cerebral en casos de esclerosis múltiple.</p> </div> </div> <div class="penci-post-box-meta "> <div class="penci-box-meta"> <span><i class="penci-faicon fa fa-clock-o" ></i><time class="entry-date published" datetime="2026-04-06T21:09:52+00:00">abril 6, 2026</time></span> <span><a href="https://www.notiulti.com/nuevo-metodo-identifica-proteinas-clave-en-respuestas-inmunitarias-nocivas/#respond "><i class="penci-faicon fa fa-comment-o" ></i>0 comments</a></span> </div> <div class="penci-post-share-box"> <a href="#" class="penci-post-like" aria-label="Like this post" data-post_id="6790804" title="Like" data-like="Like" data-unlike="Unlike"><i class="penci-faicon fa fa-heart-o" ></i><span class="dt-share">0</span></a> <a class="new-ver-share post-share-item post-share-facebook" aria-label="Share on Facebook" target="_blank" rel="noreferrer" 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src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%203%202'%3E%3C/svg%3E" alt="" title="Le-risque-de-mort-subite-dorigine-cardiaque-est-fortement-eleve.jpg" data-src="https://ma-clinique.fr/wp-content/uploads/2025/12/Le-risque-de-mort-subite-dorigine-cardiaque-est-fortement-eleve.jpg"> </a> </div> <div class="header-standard "> <div class="penci-standard-cat"><span class="cat"><a style="" class="penci-cat-name penci-cat-8" href="https://www.notiulti.com/category/salud/" rel="category tag"><span style="">Salud</span></a></span></div> <h2 class="penci-entry-title entry-title entry-title pc_titlebig_standard_df"><a href="https://www.notiulti.com/diabetes-en-mujeres-deficiencias-en-los-cuidados-preventivos/">Diabetes en mujeres: deficiencias en los cuidados preventivos</a></h2> <div class="penci-hide-tagupdated"> <span class="author-italic author vcard">by <a class="author-url url fn n" href="https://www.notiulti.com/author/editora-de-salud/">Editora de Salud</a> </span> <time class="entry-date published" datetime="2026-04-05T10:59:32+00:00">abril 5, 2026</time> </div> <div class="penci-meta-author standard-top-meta author-post byline"> <span class="author vcard">written by <a class="author-url url fn n" href="https://www.notiulti.com/author/editora-de-salud/">Editora de Salud</a> </span> </div> </div> <div class="standard-content"> <div class="standard-main-content entry-content"> <div class="post-entry standard-post-entry classic-post-entry blockquote-style-1 "> <p>Un estudio realizado por la UCLA sugiere que los médicos tienden a brindar menos cuidados preventivos a las mujeres que padecen diabetes en comparación con aquellas que no tienen esta enfermedad.</p> <p>La investigación revela que es menos probable que las mujeres con diabetes reciban ciertos servicios de salud preventiva, tales como asesoramiento sobre la concepción y algunos exámenes de detección de cáncer.</p> <p>Los resultados de este estudio fueron publicados el 3 de abril en una revista científica revisada por pares.</p> </div> </div> <div class="penci-post-box-meta "> <div class="penci-box-meta"> <span><i class="penci-faicon fa fa-clock-o" ></i><time class="entry-date published" datetime="2026-04-05T10:59:32+00:00">abril 5, 2026</time></span> <span><a href="https://www.notiulti.com/diabetes-en-mujeres-deficiencias-en-los-cuidados-preventivos/#respond "><i class="penci-faicon fa fa-comment-o" ></i>0 comments</a></span> </div> <div class="penci-post-share-box"> <a href="#" class="penci-post-like" aria-label="Like this post" data-post_id="6785669" title="Like" data-like="Like" data-unlike="Unlike"><i class="penci-faicon fa fa-heart-o" ></i><span class="dt-share">0</span></a> <a class="new-ver-share post-share-item post-share-facebook" aria-label="Share on Facebook" target="_blank" rel="noreferrer" href="https://www.facebook.com/sharer/sharer.php?u=https://www.notiulti.com/diabetes-en-mujeres-deficiencias-en-los-cuidados-preventivos/"><i 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src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%203%202'%3E%3C/svg%3E" alt="" data-src="https://i0.wp.com/www.notiulti.com/wp-content/uploads/2025/11/Une-combinaison-de-medicaments-peut-contourner-les-defenses-cellulaires-dans.jpg?fit=1170%2C99999&ssl=1"> </a> </div> <div class="header-standard "> <div class="penci-standard-cat"><span class="cat"><a style="" class="penci-cat-name penci-cat-8" href="https://www.notiulti.com/category/salud/" rel="category tag"><span style="">Salud</span></a></span></div> <h2 class="penci-entry-title entry-title entry-title pc_titlebig_standard_df"><a href="https://www.notiulti.com/vitamina-b2-clave-para-sensibilizar-celulas-cancerigenas-a-la-ferroptosis-carencia-de-vitamina-b2-aumenta-la-vulnerabilidad-del-cancer-a-la-ferroptosis-ferroptosis-y-vitamina-b2-nueva-estrategia-con/"><p><strong>Vitamina B2: Clave para Sensibilizar Células Cancerígenas a la Ferroptosis</strong></p> <p><strong>Carencia de Vitamina B2 Aumenta la Vulnerabilidad del Cáncer a la Ferroptosis</strong></p> <p><strong>Ferroptosis y Vitamina B2: Nueva Estrategia Contra el Cáncer</strong></p></a></h2> <div class="penci-hide-tagupdated"> <span class="author-italic author vcard">by <a class="author-url url fn n" href="https://www.notiulti.com/author/editora-de-salud/">Editora de Salud</a> </span> <time class="entry-date published" datetime="2026-03-15T02:08:11+00:00">marzo 15, 2026</time> </div> <div class="penci-meta-author standard-top-meta author-post byline"> <span class="author vcard">written by <a class="author-url url fn n" href="https://www.notiulti.com/author/editora-de-salud/">Editora de Salud</a> </span> </div> </div> <div class="standard-content"> <div class="standard-main-content entry-content"> <div class="post-entry standard-post-entry classic-post-entry blockquote-style-1 "> <p>Un déficit de vitamina B2, también conocida como riboflavina, puede aumentar la sensibilidad de las células tumorales a un tipo específico de muerte celular, según descubrieron investigadores del Centro Rudolf Virchow de la Universidad de Würzburg.</p> <p>El cuerpo humano no puede producir vitamina B2 por sí solo; debe obtenerla a través de la dieta. Esta vitamina se encuentra en productos lácteos, huevos, carne y verduras de hoja verde. El metabolismo la convierte en moléculas que protegen a las células del daño oxidativo, entre otras funciones.</p> <p>Investigadores del Centro Rudolf Virchow (RVZ) de la Universidad Julius-Maximilians de Würzburg (JMU) han descubierto que esta función de la vitamina también tiene un inconveniente: también protege a las células cancerosas.</p> <blockquote> <p>“La vitamina B2 juega un papel crucial en la protección de las células cancerosas contra la ferroptosis, una forma particular de muerte celular programada”, afirma Vera Skafar, estudiante de doctorado.</p> </blockquote> <p>Skafar es miembro del grupo de investigación dirigido por José Pedro Friedmann Angeli, profesor de biología celular traslacional. Los resultados se han publicado en la prestigiosa revista <em>Biología Celular Natural</em>.</p> <h2>Cómo se relacionan la vitamina B2 y la ferroptosis</h2> <p>El cuerpo humano utiliza el mecanismo de muerte celular programada para permitir que las células dañadas o peligrosas “mueran” de forma controlada sin causar inflamación en los tejidos circundantes. Específicamente, la ferroptosis está asociada con muchas patologías, incluido el cáncer y la neurodegeneración.</p> <p>A diferencia de otras vías de muerte celular, la ferroptosis se desencadena cuando la peroxidación lipídica inducida por el hierro supera la protección antioxidante de una célula. Las células cancerosas a menudo evitan la ferroptosis al reforzar los sistemas de defensa redox. Este estudio destaca el metabolismo de la vitamina B2 como un contribuyente importante a estas defensas, lo que implica que el enfoque en los cofactores derivados de la riboflavina podría debilitar la resistencia a la ferroptosis y hacer que los tumores sean más vulnerables.</p> <h2>Un inhibidor potencial</h2> <p>La proteína FSP1, un foco de investigación del grupo, es uno de los componentes responsables de proteger a las células sanas de la muerte celular. La vitamina B2 apoya a la proteína en esta tarea. Utilizando la edición del genoma y modelos de células cancerosas, los investigadores observaron que una deficiencia de la vitamina hacía que las células cancerosas fueran más susceptibles a la ferroptosis.</p> <p>Idealmente, sería posible utilizar esto con fines terapéuticos: desactivando la vía metabólica de la vitamina B2 y desencadenando así específicamente la muerte de las células cancerosas. “Sin embargo, todavía falta un inhibidor capaz de hacerlo”, explica Skafar. Los investigadores resolvieron esta limitación empleando la roseoflavina, un compuesto natural con una estructura similar a la vitamina B2 y producido por bacterias.</p> <h2>En camino hacia terapias dirigidas contra el cáncer utilizando la ferroptosis</h2> <p>En el laboratorio, el equipo del profesor Friedmann Angeli probó el principio activo en modelos de células cancerosas: “Se demostró que la roseoflavina desencadena la ferroptosis a bajas concentraciones”, explica el jefe del grupo. “Nuestros experimentos demuestran la viabilidad de este concepto”. El estudio abre así el camino al desarrollo de terapias dirigidas contra el cáncer basadas en la ferroptosis.</p> <p>En la siguiente etapa, el grupo de trabajo del RVZ se centrará en el desarrollo de inhibidores del metabolismo de la vitamina B2; el objetivo será evaluar su uso en modelos preclínicos de cáncer.</p> <p>Friedmann Angeli añade: “La ferroptosis no es solo relevante para el cáncer. Cada vez hay más evidencia que sugiere que también contribuye a los procesos patológicos de las enfermedades neurodegenerativas y a las lesiones tisulares posteriores a un trasplante de órganos o a una lesión por isquemia-reperfusión. Comprender cómo el metabolismo de la vitamina B2 influye en la ferroptosis podría tener implicaciones más amplias para las enfermedades en las que esté implicada una ferroptosis excesiva o insuficiente”.</p> <h2>Financiación</h2> <p>El estudio recibió financiación del programa prioritario “Ferroptosis: de las bases moleculares a las aplicaciones clínicas” (SPP2306) de la Fundación Alemana para la Investigación (DFG). También se llevó a cabo en el marco del proyecto DeciFerr (Deciphering and exploitating ferroptosis Regulatory Mechanism in Cancer) dirigido por el profesor Friedmann Angeli. 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